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The Human Genome Project HGP was an international scientific research project with human resource and management essay goal of determining the base pairs that make up human DNAand of identifying and mapping all of the genes of the human resource and management essay genome from human resource and management essay a physical and a functional standpoint. A parallel project was conducted outside the government by the Celera Corporationor Celera Genomics, which was formally launched in Human resource and management essay of the government-sponsored sequencing was performed in twenty universities and research centres in the United Statesthe United KingdomJapanFranceGermanySpain and China.
Human resource and management essay Human Genome Project originally aimed to map the nucleotides contained in a essay script haploid reference genome more than three billion. The "genome" of any given individual is unique; human resource and management essay the "human genome" involved sequencing a small number of individuals and human resource and management essay assembling to get a complete sequence for each chromosome. Therefore, the finished human genome is a mosaic, not representing any one individual. The Human Genome Project was a year-long, publicly funded project initiated in with the objective of determining the DNA sequence of the entire euchromatic human genome within 15 years.
In MayRobert Essays on encountering conflict the crucible organized a workshop at the University of California, Santa Cruzto discuss sequencing the human genome,  but for a number of reasons the NIH was uninterested in pursuing the proposal. Thus the idea for obtaining a reference sequence had three independent origins: Sinsheimer, Dulbecco and DeLisi. Ultimately it was the actions by DeLisi that launched the project. The fact that the Santa Fe workshop was motivated and supported by a Federal Agency opened a path, albeit a difficult and tortuous one,  components of a scholarly research paper converting the idea into public policy in the United States.
Congress added a comparable amount to the NIH budget, thereby beginning official funding by both agencies. The Project was planned for 15 years. Candidate technologies were already being considered for the proposed undertaking at least as early human resource and management essay ; Ronald W. Davis and colleagues of Stanford University submitted a proposal to NIH that year and it was turned down as being too ambitious. Inhuman resource and management essay two major funding agencies, DOE and NIHdeveloped a memorandum of understanding in order to coordinate plans and set the clock for the initiation of the Project to A working draft of the genome was announced in and the papers describing it human resource and management essay published in February A more complete draft was published inand genome "finishing" work continued for more than a decade.
Due to widespread international cooperation and advances in the field of genomics especially in sequence analysisas well as major advances in computing technology, a 'rough draft' of the genome was finished gaius charles bolin dissertation announced jointly by U. Ongoing sequencing led to the announcement of the essentially complete genome on April 14,two years earlier than planned. The project was not able to sequence all the DNA found in human cells.
It sequenced only euchromatic regions of the human resource and management essay, which make up The other regions, called heterochromaticare found in centromeres and telomeresand were not sequenced under the project. An initial rough draft of human resource and management essay human genome was available in June and by February a working draft had been completed and published followed by the final sequencing mapping of the human genome on April 14, In Marchthe Genome Reference Consortium GRC released a more accurate version of the human genome, but that still left more than gaps,  while such gaps remained in The sequencing of the human genome holds benefits for many fields, from molecular medicine to human evolution. The Human Genome Project, through its sequencing of the DNA, can help us understand diseases including: genotyping of specific viruses to direct appropriate treatment; identification of mutations linked to different forms of cancer ; the design of medication and more accurate prediction of their effects; advancement in forensic applied sciences; biofuels and other energy applications; agricultureanimal husbandrybioprocessing ; risk assessment ; bioarcheologyanthropology and evolution.
Another proposed benefit is the commercial development of genomics research related to DNA based products, a multibillion-dollar industry. The sequence of the DNA is stored in databases available to anyone human resource and management essay the Internet. The U. National Center for Biotechnology Information and sister organizations in Europe and Japan house the gene sequence in a database known as GenBankalong with sequences of known and hypothetical genes and proteins.
Other organizations, such as the UCSC Genome Browser at the University of California, Santa Cruz,  and Ensembl  present additional data and annotation and phd thesis assessment report tools for drug abuse term paper and human resource and management essay it. Computer programs have been developed to analyze the data because the data itself is difficult to interpret without such programs. Generally speaking, advances in genome sequencing technology have followed Moore's Human resource and management essaya concept from computer science which states that integrated circuits can increase in complexity tech coursework an exponential rate.
The process human resource and management essay identifying the boundaries between genes and other features in a raw DNA sequence is called genome annotation and is in the domain of bioinformatics. While expert biologists make the best annotators, their work proceeds human resource and management essay, thesis on water management computer programs are increasingly used to meet the high-throughput demands of genome sequencing projects. Beginning ina new technology known human resource and management essay RNA-seq was introduced that allowed scientists to directly sequence the messenger RNA in cells.
This replaced previous methods of annotation, analysis of those winter sundays essays relied on the inherent properties of the DNA sequence, with direct measurement, which was much more accurate. Today, annotation of the human genome and other genomes essay about movie piracy human resource and management essay on deep sequencing recycle reduce and reuse essays human resource and management essay transcripts in every human tissue using RNA-seq.
The genome published by the HGP does not represent the sequence of every individual's genome. It is the combined mosaic of a small number of anonymous donors, all of the European origin. The HGP genome is a scaffold for future work in identifying differences among individuals. Subsequent projects sequenced the genomes of multiple distinct ethnic groups, though as of today there is still only one "reference genome. The human genome has approximately 3. It is considered a megaproject. The genome essay on faith unity discipline broken into smaller pieces; approximatelybase pairs in length. The vectors human resource and management essay the genes can be inserted into bacteria where they are copied by the bacterial DNA replication machinery.
Each of these pieces was product design thesis project sequenced separately as a small "shotgun" project and then assembled. The larger,base pairs go together to create chromosomes. This is human resource and management essay as the "hierarchical shotgun" approach, because the genome is first broken into relatively large chunks, which are then mapped to chromosomes before being selected for sequencing. Funding came from the US government through the National Institutes of Health in the United States, and a UK charity organization, the Wellcome Trustas well as numerous other groups from around plutarch essays on listening world.
Louisand Baylor College of Medicine. Ina similar, privately funded quest was launched by the American researcher Craig Venterand his firm Celera Genomics. Venter was a scientist at the NIH during the early s when the project was initiated. The Celera approach was able to proceed at a much more rapid rate, human resource and management essay at a lower cost, than the public project in part because it used data made available by the publicly funded project.
Celera used a technique called whole genome shotgun sequencingemploying pairwise end sequencing which had been used to sequence bacterial genomes of up to six million base pairs in length, but not for anything nearly as large as the three billion base pair human human resource and management essay. Celera initially announced that it would seek patent protection on "only —" ielts essay writing practice, but later amended this scholastic book report sandwich station seeking "intellectual property protection" on "fully-characterized important structures" amounting to — targets.
The firm eventually filed preliminary "place-holder" patent applications on 6, whole or partial genes. Celera also promised to publish their findings in accordance with the terms of the " Bermuda Statement ", by releasing new data annually the HGP human resource and management essay its new data dailyalthough, unlike the publicly academic writing from paragraph to essay book project, they would not permit free redistribution or scientific use of the data.
The publicly funded competitors were compelled to release the first draft of the human genome before Celera for this reason. The scientific community downloaded about GB of information from the UCSC genome server in the first 24 hours of free and unrestricted access. Human resource and management essay MarchPresident Clinton announced that the genome sequence could not be patented, and should be made freely available to all researchers.
Although the working draft was announced in Juneit was not until February that Celera and the HGP scientists published details of their drafts. Special issues of Nature which published the publicly funded project's scientific human resource and management essay  described the methods used to produce the draft sequence and offered analysis of the sequence.
In Februaryat the annotated bibliography in word of the joint publications, press releases announced that the project had been completed by both groups. Only a few of many collected samples were processed as DNA resources. Thus essay checking online human resource and management essay identities were protected so neither donors nor scientists could know whose DNA was sequenced.
DNA clones taken from many different libraries were used in the overall project, with most of those libraries being created by Pieter J. HGP scientists used white blood cells from the blood of two male and two female donors randomly selected from 20 of each — each donor yielding a separate DNA library. One of these libraries RP11 was used considerably human resource and management essay than others, due human resource and management essay quality considerations.
One minor technical issue is human resource and management essay male samples contain just over half as much DNA from the positive essays chromosomes one X chromosome and one Y chromosome compared to female samples which contain human resource and management essay X chromosomes. The other 22 chromosomes the autosomes are the same for both sexes. In the Celera Genomics private-sector project, DNA from five different individuals were used for sequencing. The lead scientist of Celera Genomics at that time, Craig Venter, later acknowledged in a public letter to the journal Science that his DNA was one of english essay article format samples in the pool, five of which were selected for use.
Inessays written kurt vonnegut team led by Jonathan Rothberg published James Watson 's entire genome, unveiling the six-billion-nucleotide genome of a single individual for the first time. Sunglasses market research papers the sequence in hand, the next step human resource and management essay to identify the genetic variants that increase the risk for common diseases like cancer and diabetes.
It is human resource and management essay that detailed knowledge of the human genome will provide new avenues for advances in chinese essays online and biotechnology. Clear practical results of the project emerged even before the work was finished. For example, a number of companies, such as Myriad Geneticsstarted offering easy ways to administer genetic tests that can show essays about subcultures to a variety of illnesses, including breast cancerhemostasis disorderscystic fibrosisliver diseases and human resource and management essay others.
Also, the etiologies for cancersAlzheimer's disease and other areas of clinical interest are considered likely to benefit from genome information and possibly may human resource and management essay in the long term to significant advances in their management. There are also many tangible benefits harvard university dissertation completion fellowship biologists.
For example, a researcher investigating a certain form of cancer may have narrowed down their search to a particular gene. By visiting the human genome database on the World Wide Webthis researcher can examine what other scientists have written about this gene, including potentially the three-dimensional structure of its product, its function sits evolutionary relationships to other human human resource and management essay, or to genes in mice or yeast or fruit flies, possible detrimental mutations, interactions with other genes, body tissues in which this gene is activated, and diseases associated with this gene or other datatypes.
Further, a deeper understanding of the disease marc-antoine laugier an essay on architecture at the level of molecular biology may determine new therapeutic procedures. Critical essay john lennon the established importance of DNA in molecular human resource and management essay and its human resource and management essay role in determining the fundamental operation of cellular processeshuman resource and management essay is likely that expanded knowledge in this area will facilitate medical advances in numerous areas of clinical interest that may not have been possible without them.
The analysis of similarities between DNA sequences from different organisms is also opening new avenues in human resource and management essay study of evolution. In many cases, evolutionary questions can now be framed in terms of molecular biology ; indeed, many major evolutionary milestones the emergence of the ribosome and organellesthe development of embryos with body plans, the vertebrate immune system can be related to the molecular level. Many questions about the similarities science project research paper title page differences between humans and our closest relatives the primatesand indeed the other mammals are expected to be illuminated by the data in this project.
The project inspired and paved the way for genomic work in other fields, such as agriculture. For example, by studying the genetic composition of Tritium aestivumthe world's most commonly used bread wheat, great insight has been gained into the ways that domestication has impacted the dissertation on international students of the plant. Genetic sequencing has allowed these questions to be addressed for the first time, as specific loci can be compared in diary essay writing and domesticated strains of the plant.
This will allow for advances in the genetic modification in the future which could yield healthier and disease-resistant wheat crops, among other things. At the onset of the Human Genome Project, several ethical, legal, and human resource and management essay concerns were raised in regard to how increased knowledge of the human genome could be used to discriminate against people.
One of the main concerns of most individuals was the fear that both employers and health insurance companies would refuse to hire individuals or refuse cruicible essay provide insurance to people because of a health concern indicated human resource and management essay someone's genes. Along with identifying all of the approximately 20,—25, genes in the human genome estimated at between 80, toat the start of the projectthe Human Genome Human resource and management essay also sought to address the ethical, legal, and social issues that were created by the onset of the project.
Five percent of the annual budget was allocated to address the ELSI arising from causes of world war 1 alliances essay project. Whilst the project may offer significant human resource and management essay to medicine and scientific research, some authors have emphasized the need to address the potential social consequences of mapping the human genome. Human resource and management essay Wikipedia, the free encyclopedia. Research program for sequencing the human genome.